![]() In study 1, eight healthy volunteers ingesting 600 ml/day water or grapefruit juice for 10 days took a single oral 0.8-mg dose of alprazolam on the eighth day. The effects of repeated ingestion of grapefruit juice, an inhibitor of cytochrome P450 3A4 (CYP3A4), on the pharmacokinetics and pharmacodynamics of both single and multiple oral doses of alprazolam, a substrate of CYP3A4, were examined. This leads me to believe that perhaps those benzos and other drugs that get absorbed better in the GI track can be potentiated better with GFJ simply because it primarily inhibits CYP3A4 enzymes in the GI track and only weakly inhibits those enzymes in the liver. ![]() Thus, in order for potentiation to occur, you need the hepatic CYP3A4 enzymes to be inhibited not just those that exist in your gut.Īlprazolam is listed on the right side of wiki as being metabolized by hepatic CYP3A4 also, but under the pharmacokinetics section it claims that it is rapidly absorbed in the GI track. So perhaps the reason Clonazepam, and I assume then other nitro-substituted benzos are only weakly (if at all) affected by GFJ is that you simply need to ingest a lot of it to get hepatic inhibition.Ĭlonazepam is metabolized hepaticly (not sure if that's the correct term), ie. But also interestingly enough it says hepatic inhibition only occurs at higher doses (of GFJ). I gives a list of the 2-3 chemicals in grapefruit responsible for CYP 3A4 inhibition. Well i've got a bottle full of klonopin, I'll try to remember get some white GFJ this weekend and do a few tests for myself.Īgain this is only from wiki but reading here: I couldn't walk straight, but I still remember it fairly well and it's like my motor functions were affected more than anything else. The only times I actually got kind of tipsy from benzos without taking alcohol was when I mixed it with 50mg Meperidine + 100mg Promethazine. If I wasn't bored, I could have stayed up easily. One time I took ~25mg Valium and ~4mg Klonopin, and I went to school and did fine on all my tests. I think I have a rather large natural tolerance to benzodiazepines, because threshold effects of Valium for me start at ~15mg, and for Klonopin it's about 3mg. My preferred dose for fun is like 20mg Valium + 4mg Klonopin, but my Valium and the rest of my Klonopin has been long gone. I want to have fun with my last bit of Klonopin 1.75mg, but I will barely notice it at this dose. yea, I'm not worried about any dangers of over-potentiation. people tell you to stop worrying, but it's hard to stop if you don't even realize that you ARE worrying and being self-conscience.Īnyways. It's been two weeks since then and I'm still fine. I stopped caring what people though, and ta-dah. I got over the anxiety I was scripted for after a day of DXM when I realized that I was causing all the anxiety myself. My question was regarding recreational use.
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